Back in the day, we had several clients who ran MAS 200 over slower connections, such as a T1, VPN, or DSL connection with decent results. However, that was under 3x technology. Recently, our experiences have been significantly less positive under the new framework.
I have a client who tried to run across a VPN and experienced a great amount of speed degradation. I don't have the specs on the speed but up speeds were 5 mb or higher (which is the equivalent of 3.3333 T1 at 1.5 mb each). They run core, distribution, mfg, Sage CRM, Star Ship, and a few other gems. Creating an SO integrated with a CRM opportunity took several minutes to save. SO Invoice posting took a couple minutes per transaction. It worked but not in the realm of what anyone would call acceptable.
TS resolved most of the speed issues.
I'm thrilled with the new framework and will gladly give up remote processing for the improvements gained. We just won't go back to operating over a remote session over a VPN again in the foreseeable future unless improvements are made to the based system. If the client to server connection is less than 100 mb, we ain't playin' the remote workstation game.