@EricAnderson our largest ever customer has 120 seats with 8 business locations (local Indian nation with gaming facilities spread across part of the state). It worked ok but remote printing was a pain on a regular basis. I wouldn't want to do another one that large. I required a lot of TLC to keep running smoothly.
If you do go down that road, just understand you are in an enterprise environment and they need an IT professional on staff. A real IT professional, not a tinkerer or a workstation tech. Server moves, upgrades, remote printing, terminal server management, IP routing; lots to birth, grow, and feed.
BTW, they eventually moved from MAS 200 to Peoplesoft. That will give you an idea of volume and size.