Same here re: Sage CRM, although I'm unaware how it was ultimately resolved because the client (4.5.3) typically handles their Sage CRM related stuff on their own. Also, if it works fine in a test company which isn't integrated with Sage CRM, you can then try disabling the Integration Engine to see what happens in the live company.
Do you know if this issue is happening on all workstations? I think with my client we had thoughts that it was somehow related to the workstations but I can't be sure.
@KerryEsser, do you recall how your client ended up resolving it once they isolated it to Sage CRM?