The McCormick Place area is HUGE. But it is a bit isolated. There are hotels nearby or you can stay in the Loop area and take a cab/bus to the event. Not really walkable (unless you are Wayne).
Google link below gives you an idea of the location layout. Much more remote and spread out than Vegas was.
https://www.google.com/maps/search/Hotels/@41.8500912,-87.6350887,14z/data=!3m1!4b1!4m8!2m7!3m6!1sHotels!2sMcCormick+Place,+2301+S+Lake+Shore+Dr,+Chicago,+IL+60616,+United+States!3s0x880e2b8114325857:0xde54f80e4327f5e2!4m2!1d-87.6159559!2d41.8499384