See attached file for support matrix. This only talks about SageCRM - not MAS 4.5 so you will need to check on that separately.
Everyone should head to
http://community.sagecrm.com for more on Sage CRM. And of course head to
www.azambapartners.com - I'm updating that once per week now to help address marketing and sales questions re: Sage CRM.
@JohnnyPabian - Where did you hear that Sage CRM cannot be installed on the same machine as Exchange? I can say from experience that is not correct for older versions of SageCRM. On the other hand ... it's not recommended because Exchange is such a resource pig. Because of that, we haven't done it for years and I'm not 100% sure about Sage CRM 7.0 or 7.1 being installed on the same box as Exchange.